MHCherryPan, a novel pan-specific model for binding affinity prediction of class I HLA-peptide

Abstract:
The human leukocyte antigen (HLA) system or complex playsan irreplaceable role in regulating the humans’ immune system. Accurate prediction of peptide binding with HLA can efficiently promote to identify those neoantigens, which potentially make a great change in immune drug development. HLA is one of the most polymorphic genetic systems in humans,and thousands of HLA allelic versions exist. Due to the high polymorphism of HLA complex, it is still pretty difficult to accurately predict the binding affinity. In this paper, we proposed a novel algorithm which combined convolutional neural network and long short-term memory to solve this problem. Our model has been tested with the experimental benchmark from IEDB and shows the state-of-the-art performance compared with other currently popular algorithms

Suggested citation:
Xuezhi Xie, et al. MHCherryPan, a novel pan-specific model for binding affinity prediction of class I HLA-peptide, Int. J. Data Mining and Bioinformatics , Vol. 24, No. 3, 2020